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Pengming SUN PhD, MD , Jalid SEHOULI PhD, MD , Lihui WEI BM ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 256-264 doi: 10.1007/s11684-009-0052-3
关键词: target therapy gynecologic malignant tumors clinical trail molecular medicine
Ontological reconstruction of the clinical terminology of traditional Chinese medicine
null
《医学前沿(英文)》 2014年 第8卷 第3期 页码 358-361 doi: 10.1007/s11684-014-0348-9
This study proposes the ontological reconstruction of the current clinical terminology of traditional Chinese medicine (TCM). It also provides an overview of preliminary work related to the said reconstruction, including the ontology-based analysis of TCM clinical terminology. We conclude that the ontological reconstruction of TCM clinical terminology provides a proper translation from the idealized organizational model to real-world implementation and to a formalized, shared, and knowledge-based framework.
关键词: ontology traditional Chinese medicine clinical terminology
《医学前沿(英文)》 2023年 第17卷 第3期 页码 527-533 doi: 10.1007/s11684-022-0967-5
关键词: orthotopic heart transplant tricuspid regurgitation clinical impact biatrial heart transplantation
Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment
null
《医学前沿(英文)》 2017年 第11卷 第3期 页码 340-348 doi: 10.1007/s11684-017-0570-3
In light of the rapid increase in the number of obesity incidences worldwide, obesity has become an independent risk factor for chronic kidney disease. Obesity-related glomerulopathy (ORG) is characterized by glomerulomegaly in the presence or absence of focal and segmental glomerulosclerosis lesions. IgM and complement 3 (C3) nonspecifically deposit in lesions without immune-complex-type deposits during ORG immunofluorescence. ORG-associated glomerulomegaly and focal and segmental glomerulosclerosis can superimpose on other renal pathologies. The mechanisms under ORG are complex, especially hemodynamic changes, inflammation, oxidative stress, apoptosis, and reduced functioning nephrons. These mechanisms synergize with obesity to induce end-stage renal disease. A slow increase of subnephrotic proteinuria (<3.5 g/d) is the most common clinical manifestation of ORG. Several treatment methods for ORG have been developed. Of these methods, renin–angiotensin–aldosterone system blockade and weight loss are proven effective. Targeting mitochondria may offer a novel strategy for ORG therapy. Nevertheless, more research is needed to further understand ORG.
关键词: obesity-related glomerulopathy pathogenesis pathologic clinical characteristics
Coronavirus disease 2019 (COVID-19): a clinical update
Min Zhou, Xinxin Zhang, Jieming Qu
《医学前沿(英文)》 2020年 第14卷 第2期 页码 126-135 doi: 10.1007/s11684-020-0767-8
关键词: coronavirus disease 2019 epidemiology pathology radiology clinical characteristics treatment
Hypertension in patients with CKD in China: clinical characteristics and management
null
《医学前沿(英文)》 2017年 第11卷 第3期 页码 307-309 doi: 10.1007/s11684-017-0578-8
《医学前沿(英文)》 2022年 第16卷 第4期 页码 551-573 doi: 10.1007/s11684-022-0928-z
关键词: HCC bone osteotropism clinical basic researches advances
Heterogeneity of the tumor immune microenvironment and clinical interventions
《医学前沿(英文)》 2023年 第17卷 第4期 页码 617-648 doi: 10.1007/s11684-023-1015-9
《医学前沿(英文)》 doi: 10.1007/s11684-023-1043-5
关键词: coronavirus disease 2019 SARS-CoV-2 epidemiology clinical features
Genetic and clinical markers for predicting treatment responsiveness in rheumatoid arthritis
Xin Wu, Xiaobao Sheng, Rong Sheng, Hongjuan Lu, Huji Xu
《医学前沿(英文)》 2019年 第13卷 第4期 页码 411-419 doi: 10.1007/s11684-018-0659-3
Biological properties and clinical applications of berberine
Danyang Song, Jianyu Hao, Daiming Fan
《医学前沿(英文)》 2020年 第14卷 第5期 页码 564-582 doi: 10.1007/s11684-019-0724-6
关键词: berberine Coptis chinensis pharmacological properties mechanism clinical applications
Anatomy and embryology of umbilicus in newborns: a review and clinical correlations
null
《医学前沿(英文)》 2016年 第10卷 第3期 页码 271-277 doi: 10.1007/s11684-016-0457-8
Umbilicus is considered a mirror of the abdomen in newborns. Despite its importance, the umbilicus has been stated in literature and textbooks as discrete subjects with many body systems, such as the urinary, digestive, and cardiovascular ones. This article aimed to address the basic knowledge of the umbilicus in relation to clinical disorders under one integrated topic to aid physicians and surgeons in assessing newborns and infants. The umbilicus appears as early as the fourth week of fetal life when the folding of the embryonic plate occurs. The umbilicus appears initially as a primitive umbilical ring on the ventral aspect of the body. The primitive umbilicus contains the connecting stalk, umbilical vessels, vitelline duct and vessels, allantois, and loop of the intestine. Changes occur to form the definitive cord, which contains three umbilical vessels, namely, “one vein and two arteries,” embedded in Wharton’s jelly. After birth, the umbilical vessels inside the body obliterate and gradually form ligaments. Congenital disorders at the umbilicus include herniation, bleeding, and discharge of mucous, urine, or feces. Some of these disorders necessitate emergent surgical interference, whereas others may be managed conservatively. The umbilicus has many embryological remnants. Thus, the umbilicus is prone to various clinical disorders. Detecting these disorders as early as possible is essential to prevent or minimize possible complications.
《医学前沿(英文)》 2022年 第16卷 第3期 页码 389-402 doi: 10.1007/s11684-021-0856-3
关键词: severe community-acquired pneumonia lung microbiota clinical improvements 7-category ordinal scale Prevotellaceae
Scientific computation of big data in real-world clinical research
null
《医学前沿(英文)》 2014年 第8卷 第3期 页码 310-315 doi: 10.1007/s11684-014-0358-7
The advent of the big data era creates both opportunities and challenges for traditional Chinese medicine (TCM). This study describes the origin, concept, connotation, and value of studies regarding the scientific computation of TCM. It also discusses the integration of science, technology, and medicine under the guidance of the paradigm of real-world, clinical scientific research. TCM clinical diagnosis, treatment, and knowledge were traditionally limited to literature and sensation levels; however, primary methods are used to convert them into statistics, such as the methods of feature subset optimizing, multi-label learning, and complex networks based on complexity, intelligence, data, and computing sciences. Furthermore, these methods are applied in the modeling and analysis of the various complex relationships in individualized clinical diagnosis and treatment, as well as in decision-making related to such diagnosis and treatment. Thus, these methods strongly support the real-world clinical research paradigm of TCM.
关键词: big data real world clinical research Chinese medicine medical computing
Clinical acupuncture research in the West
Xianze Meng, Shifen Xu, Lixing Lao
《医学前沿(英文)》 2011年 第5卷 第2期 页码 134-140 doi: 10.1007/s11684-011-0135-9
关键词: acupuncture clinical research research methodology the West
标题 作者 时间 类型 操作
Molecular targeted therapy of gynecological malignant tumors: the development and challenge, from laboratory to clinic
Pengming SUN PhD, MD , Jalid SEHOULI PhD, MD , Lihui WEI BM ,
期刊论文
The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant
期刊论文
Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment
null
期刊论文
Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives
期刊论文
Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China
期刊论文
Genetic and clinical markers for predicting treatment responsiveness in rheumatoid arthritis
Xin Wu, Xiaobao Sheng, Rong Sheng, Hongjuan Lu, Huji Xu
期刊论文
Biological properties and clinical applications of berberine
Danyang Song, Jianyu Hao, Daiming Fan
期刊论文
Clinical factors associated with composition of lung microbiota and important taxa predicting clinical
期刊论文